Study shows that the aggressive Lone Star tick is no match for Credelio

GREENFIELD, Indiana., 15 August 2024 /PRNewswire/ — Parasites and vectorsa leading peer-reviewed journal focusing on parasites and vector-borne pathogens, published the results of a comparative study showing that Credelio, a prescription flea and tick protection product from Elanco Animal Health, kills ticks the fastest, with an initial rate of only 12 hours, and maintains this benefit throughout the dosing interval.^1,2,3 According to the Centers for Disease Control (CDC), state and local health departments reported more than 45,000 cases of tick-borne diseases in humans to the CDC between 2019 and 2022.⁴ The Companion Animal Parasite Council (CAPC) recommends using products on pets that kill and/or repel ticks before pathogens are transmitted.⁵

The 2023 study compared three popular prescription flea and tick treatments for dogs, Credelio (lotilaner), Simparica TRIO (sarolaner, moxidectin, pyrantel), and NexGard (afoxolaner), and tracked the comparative data for the relative kill rates of American Amblyomma (Lone Star Tick) – an aggressive and spreading tick that lives in the United States this is one of the hardest ticks to kill. Not only is this tick difficult to kill, but it can also transmit dangerous pathogens to pets and people. The CDC recently provided detailed tick surveillance information about the aggressive nature of the Lone Star tick, which can bite people and transmit bacterial and viral pathogens, as well as cause Alpha-Gal Syndrome (red meat allergy).⁶

“The results of this head-to-head study show Credelio as the leader in speed of tick killing among prescription flea and tick treatment products for dogs.¹ The longer a tick is attached, the greater the risk of pathogen transmission,” says Dr. Kathryn ReifBailey-Goodwin Endowed Professor of Parasitology at the Auburn University. “These pathogens can cause serious illnesses such as Rocky Mountain spotted fever and ehrlichiosis, so it’s important that veterinarians talk to pet owners about year-round parasite protection. Credelio’s fast and sustained tick kill helps protect pets from disease-carrying ticks that can cause dangerous diseases.”¹

The study involved dogs that were randomly assigned to one of four treatment groups: Credelio, Simparica TRIO, NexGard, or untreated control.

• At regular intervals, blind investigators carried out tick counts on dogs.¹
• The study results showed that in all 12-hour evaluation intervals, only the Credelio group significantly reduced the number of Lone Star ticks compared to the untreated control group.
• The study found that the Simparica TRIO and NexGard groups did not differ significantly from the untreated control group at any of the 12-hour evaluation intervals.
• The study also showed that Credelio significantly reduced tick counts at all 12- and 24-hour evaluation time points and that only Credelio provided such a rapid kill rate throughout the entire one-month treatment period.^1,2,3
• Of the products tested, only Credelio killed ticks as quickly at the end of the month as at the beginning.

“This study sets Credelio apart from the competition as it maintains a high tick kill rate throughout the entire monthly dosing period,” said David GoescheDVM, Elanco Sr. Director of Technical Marketing.^1,2,3 “This product demonstrates consistent tick killing effectiveness throughout the month and outperforms the competing products tested.” ^1,2,3

Learn more about Credelio for dogs here. Click here to read the full study results.

About Elanco

Elanco Animal Health Incorporated (NYSE: ELAN) is a global animal health leader committed to developing and delivering products and services that prevent and treat disease in livestock and companion animals, creating value for farmers, livestock producers, veterinarians, stakeholders and society at large. With nearly 70 years of experience in animal health, we are committed to helping our customers improve the health of the animals in their care while making a meaningful impact on our local and global communities. At Elanco, we are driven by our vision of “Food and Companionship that Enriches Lives” and our Elanco Healthy Purpose™ sustainability initiatives – all to advance the health of animals, people and the planet.

CREDELIO INDICATIONS

Credelio kills adult fleas and is suitable for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations (American Amblyomma (lonely star), Dermacentor variabilis (American dog tick), Ixodes scapularis (Blacklegged tick) and Rhipicephalus sanguineus (Brown dog tick)) for one month in dogs and puppies aged 8 weeks and over and weighing at least 2 kg.

CREDELIO IMPORTANT SAFETY INFORMATION

Lotilaner belongs to the isoxazoline group of drugs. This group is associated with neurological side effects such as tremors, ataxia and seizures. Seizures have been reported in dogs receiving this group of drugs, even in dogs with no history of seizures. Caution should be exercised in dogs with a history of seizures or neurological disorders. The safe use of Credelio in breeding dogs, pregnant or lactating dogs has not been studied. The most commonly reported side effects are weight loss, increased blood urea nitrogen, polyuria and diarrhea. For full prescribing information, see the Credelio package insert.

NexGard is a registered trademark of Boehringer Ingelheim Animal Health USA Inc. Simparica TRIO is a registered trademark of Zoetis Services LLC.

Credelio, Elanco and the diagonal bar logo are trademarks of Elanco or its subsidiaries. Other company and product names are trademarks of their respective owners. © 2024 Elanco or its subsidiaries

PM-US-24-1168

¹ American Ambylomma (lone star)
² Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative kill rate of lotilaner (Credelio™), sarolaner (Simparica Trio™) and afoxolaner (NexGard™) for control American Amblyomma Infestation in dogs. Parasite vectors. 2024 Jul 20;17(1):313.
³ Based on time to statistical significance compared to control in a single study at days 21 and 28 of rechallenge.
⁴ Centers for Disease Control and Prevention. (nd). Summary of surveillance data on tick-borne diseases. Centers for Disease Control and Prevention. Retrieved 8 August 2024from https://www.cdc.gov/ticks/data-research/facts-stats/tickborne-disease-surveillance-data-summary.html?CDC_AAref_Val=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fdata-summary%2Findex.html
⁵ Pet Parasites Council | Pet Parasites Annual Forecasts 2023 (capcvet.org)
⁶ Centers for Disease Control and Prevention. (nd). Where ticks live. Centers for Disease Control and Prevention. Retrieved 8 August 2024from https://www.cdc.gov/ticks/about/where-ticks-live.html

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